Symptoms and Signs of Retroperitoneal Fibrosis

Retroperitoneal Fibrosis is abnormal tissue expansion frequently spreads to influence the tubes which take urine from the kidney into the bladder (ureters). Frequently these tubes become blocked with the extra tissue. Specific symptoms may change depending upon the precise location of tissue expansion and how much it spreads. Generally, the cause of the disease is unknown (idiopathic).

Symptoms and Signs

The Most frequent symptom of retroperitoneal fibrosis is the pain in the back or stomach. Often that pain is dull, vague and hard to localize. Further symptoms can be weight loss, fever, nausea, and a minimal level of circulating red blood cells (anemia), and lack of desire. An impaired motion of a limb might happen intermittently, and strange yellowish discoloration (pigmentation) of skin and the whites of their eyes (jaundice) can be present. Swelling of one leg could also happen. Decreased blood flow to the leg might lead to discoloration and pain.

Sometimes there may be bleeding (hemorrhaging) from the gut and Gut. In about ten percent of those cases, there might be trouble urinating. Upon evaluation by a doctor, a mass could be felt in the rectum or gut in roughly 15 percent of people with this disease. Sometimes, obstruction of one or both of those tubes that carries urine from the bladder to the bladder (ureters) can also happen (unilateral or bilateral obstructive uropathy).

Depending on where the barrier occurs, the accumulation of Substance might cause the pelvis and bladder bacterium getting bloated with pee (hydronephrosis).

In rare situations, retroperitoneal fibrosis might become malignant. In certain Affected people, the largest vein in the body which returns blood to the heart (inferior vena cava) can be straightened from the fibrous tissues. This encasement infrequently causes obstruction of the vein.

Retroperitoneal Fibrosis

Reasons

The Precise reason for retroperitoneal fibrosis isn’t known in roughly two-thirds of those affected people (idiopathic). A medication often used in the prevention and treatment of migraine headaches (methysergide) might be the source of the uncommon illness in 12% of cases. Malignant tumors are associated with retroperitoneal fibrosis in eight % of affected people. Tissue that’s been injured by injury or surgery might be an element sometimes.

Retroperitoneal Fibrosis affects men twice as frequently as females. Nearly all cases occur in people between 40 and 60 decades old. On the other hand, the disease can happen at any age, though it’s very rare in children.

Connected Diseases

Symptoms Comparisons may be Helpful for a differential diagnosis:

  • Carcinoid Syndrome is a rare, cancerous disease that affects the Small intestine, pancreas, or gut. Slow growing tumors may spread into the lungs, liver, and gut. Signs of the disease may include flushing, nausea, nausea, stomach pain, and blockage of blood vessels. (For more details about this disorder, select “Carcinoid ” as your search phrase in the Rare Disease Database.)
  • A scleroderma is a group of chronic diseases characterized by (For more details about this disorder, select “Scleroderma” as your search phrase in the Rare Disease Database.)
  • Includes the arteries, veins, and capillaries. This disease may occur independently or along with contagious and rheumatic ailments. (For more details about this disorder, select “Vasculitis” as your search phrase in the Rare Disease Database.)
    Treatment of retroperitoneal fibrosis is dependent upon the location and degree of the tissue development.
  • Surgery is often quite effective in preventing manhood that has been Surgery may also be used to get rid of a fibrous mass. Obstruction of the ureter can be treated with ureterolysis; a surgical process used to spare a ureter from surrounding tissue (e.g.( abnormal fibrous tissue). Sometimes, stents might be implanted inside the ureter to present temporary relief from obstruction.
  • Corticosteroid medication therapy may be Utilized at the early stages of this Disorder, together with an operation, or in impacted people that are at elevated risk if an operation is done.

Sometimes, abnormal fibrous expansion can recur months or years After an operation or steroid treatment. Sometimes, doctors may wrap a Layer of fat around the ureter in an endeavor to protect against the recurrence In some reported instances, retroperitoneal fibrosis

 

Supporting Organizations

References

TEXTBOOKS

Schumacher Jr, HR. Multifocal fibrosclerosis. In: Bennett JC and Plum F, Eds. Cecil Textbook of Medicine, 20th ed. Philadelphia, PA: W.B. Saunders Co; 1996:1529.

Yamada T, et al., eds. Textbook of Gastroenterology. 2nd ed. Philadelphia, PA: J.B. Lippincott Company; 1995:2317.

JOURNAL ARTICLES

  • Meier P, et al. Retroperitoneal fibrosis, an unrecognized inflammatory disease. Clinical observations and review of the literature. Nephrologie. 2003;173-80.
  • Elinav H, et al. Retroperitoneal fibrosis – clinical response to steroid treatments. Harefuah. 2003;142:166-69.
  • Kardar AH, et al. Steroid therapy for idiopathic retroperitoneal fibrosis: dose and duration. J Urol. 2002;168:550-55.
  • Bani-Hani KE, et al. Retroperitoneal fibrosis. Demographic, clinical and pathological findings. Saudi Med J. 2002;23:711-15.
  • Pierre S, et al. Retroperitoneal fibrosis: a case report of spontaneous resolution. Clin Nephrol. 2002;57:314-19.
  • Monev S. Idiopathic retroperitoneal fibrosis: prompt diagnosis preserves organ function. Cleve Clin J Med. 2002;69:160-66.
  • Onuigbo M, et al. Retroperitoneal fibrosis: the unusual cause of low back pain. South Med J. 2001;94:735-37.
  • Dedeoglu F, et al. Successful treatment of retroperitoneal fibrosis with tamoxifen in a child. J Rheumatol. 2001;28:1693-95.
  • Inoue T, et al. A case of retroperitoneal fibrosis responding to steroid therapy. Hinyokika Kiyo. 2001;47:321-24.
  • Lachkar A, et al. Treatment of idiopathic retroperitoneal fibrosis. Ann Urol (Paris). 2001;35:148-50.
  • Demko TM, et al. Obstructive nephropathy as a result of retroperitoneal fibrosis: a review of its pathogenesis and associations. J Am Soc Nephrol. 1997;8:684-88.
  • Klisnick A, et al. Combined idiopathic retroperitoneal and mediastinal fibrosis with pericardial involvement. Clin Nephrol. 1999;52:213-15.
  • Fujii K, et al. Localized nodular idiopathic retroperitoneal fibrosis: successful treatment with surgical resection. Pancreas. 1999;19:213-15.
  • Moroni G, et al. Retroperitoneal fibrosis and membranous nephropathy. Improvement of both diseases after treatment with steroids and immunosuppressive agents. Nephrol Dial Transplant. 1999;14:1303-05.
  • Grotz W, et al. Treatment of retroperitoneal fibrosis by mycophenolate mofetil and corticosteroids. Lancet. 1998;352:1195.
  • al-Musawi D et al. Idiopathic retroperitoneal fibrosis treated with tamoxifen only. Br J Urol. 1998;82:442-43.

Years Published

1991, 1999, 2002, 2003

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